上海硅酸盐研究所—介孔与低维纳米材料课题组

杨博文

　　杨博文，中国科学院上海硅酸盐研究所副研究员。博士毕业于中国科学院上海硅酸盐研究所（导师：施剑林）。研究工作主要围绕“纳米催化医学”，通过构建新型纳米药物在病灶引发催化反应，调控局域活性氧浓度，以达到疾病治疗的目的。近年来发展纳米催化抗氧化疗法，利用纳米催化剂高效清除人体活性氧，实现心血管疾病和各类炎症的抗氧化治疗。现以通讯/第一作者身份在J. Am. Chem. Soc.（4篇）、Angew. Chem. Int. Ed.（5篇）、Nat. Commun.（2篇）、Chem（2篇）、Adv. Mater.（4篇）、Acc. Chem. Res.（1篇）、Chem. Rev.（1篇）等期刊发表论文30余篇。7篇论文入选ESI高被引，总引用次数超过5000。获得中国科学院院长特别奖、中国化学会菁青化学星火奖、京博优秀博士论文奖等荣誉和奖励。主持国家自然科学基金青年基金。入选上海市青年科技启明星（A类）。连续多年入选爱思唯尔/斯坦福大学全球前2%顶尖科学家榜单（2022-2025）。

联系方式

电话：021-52412706

邮箱：yangbowen@mail.sic.ac.cn

研究方向

I. 退行性疾病（心血管疾病、类风湿关节炎）催化抗氧化治疗

II. 肿瘤纳米催化治疗

代表性论文

Bowen Yang* and Jianlin Shi*. Nanocatalytic Antioxidation: A General Chemical Approach for Alleviating Oxidative Stress in Diseases. Accounts of Chemical Research 2025, 58, 2708-2723.
Yufan Yao, Bowen Yang*, and Jianlin Shi*. TiO_x(OH)_4-2x Nanosheets with Catalytic Antioxidative Activity Alleviate Oxidative Injury in Diabetic Cardiomyopathy. Journal of the American Chemical Society 2025, 147, 3885-3895.
Di Jiang, Bowen Yang*, and Jianlin Shi.Antioxidative Therapy of Alcoholic Liver Injury by an Amorphous Two-Dimensional Cobalt Hydroxide Nanocatalyst. Angewandte Chemie International Edition 2025, 64, e202412031.
Bowen Yang and Jianlin Shi*. Generalized Concept of Catalysis for Chemical Reactions: Nanocatalysis in Medicine as a Paradigm. Chem 2025, 11, 102549.
Bowen Yang, Chengkai Hu, Yuchong Zhang, Di Jiang, Peng Lin, Shouji Qiu, Jianlin Shi* and Lixin Wang*. Biomimetic-Structured Cobalt Nanocatalyst Suppresses Aortic Dissection Progression by Catalytic Antioxidation. Journal of the American Chemical Society2024, 146, 17201-17210.
Jiacai Yang, Bowen Yang*, and Jianlin Shi*. A Nanomedicine-Enabled Ion-Exchange Strategy for Enhancing Curcumin-Based Rheumatoid Arthritis Therapy. Angewandte Chemie International Edition 2023, 62, e202310061.
Jiacai Yang, Heliang Yao, Yuedong Guo, Bowen Yang*, and Jianlin Shi*. Enhancing Tumor Catalytic Therapy by Co-Catalysis. Angewandte Chemie International Edition 2022, 61, e202200480.
Bowen Yang, Heliang Yao, Jiacai Yang, Chang Chen, and Jianlin Shi*. Construction of a Two-Dimensional Artificial Antioxidase for Nanocatalytic Rheumatoid Arthritis Treatment. Nature Communications 2022, 13, 1988.
Bowen Yang, Heliang Yao, Jiacai Yang, Chang Chen, Yuedong Guo, Hao Fu, and Jianlin Shi*. In Situ Synthesis of Natural Antioxidase Mimics for Catalytic Anti-Inflammatory Treatments: Rheumatoid Arthritis as an Example. Journal of the American Chemical Society2022, 144, 314-330.
Bowen Yang, Heliang Yao, Han Tian, Zhiguo Yu, Yuedong Guo, Yuemei Wang, Jiacai Yang, Chang Chen, and Jianlin Shi*. Intratumoral Synthesis of Nano-Metalchelate for Tumor Catalytic Therapy by Ligand Field-Enhanced Coordination. Nature Communications 2021, 12, 3393.
Bowen Yang and Jianlin Shi*. Ascorbate Tumor Chemotherapy by an Iron-Engineered Nanomedicine-Catalyzed Tumor-Specific Pro-Oxidation. Journal of the American Chemical Society 2020, 142, 21775-21785.
Bowen Yang, Yu Chen*, and Jianlin Shi*. Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization. Angewandte Chemie International Edition 2020, 59, 9693-9701.
Bowen Yang and Jianlin Shi*. Developing New Cancer Nanomedicines by Repurposing Old Drugs. Angewandte Chemie International Edition2020, 59, 21829-21838.
Bowen Yang, Li Ding, Heliang Yao, Yu Chen*, and Jianlin Shi*. A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition. Advanced Materials 2020, 32, 1907152.
Bowen Yang, Yu Chen*, and Jianlin Shi*. Reactive Oxygen Species (ROS)-based Nanomedicine. Chemical Reviews 2019, 119, 4881-4985.
Bowen Yang, Yu Chen*, and Jianlin Shi*. Nanocatalytic Medicine. Advanced Materials 2019, 31, 1901778.
Bowen Yang, Junhui Yin, Yu Chen*, Shanshan Pan, Heliang Yao, Youshui Gao*, and Jianlin Shi* 2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma. Advanced Materials 2018, 30, 1705611.

专利

1. 一种具有催化抗氧化性能的二维金属有机框架纳米片及其制备方法和应用；ZL202210163113.8；施剑林，杨博文