杨博文
杨博文，中国科学院上海硅酸盐研究所副研究员。2022年博士毕业于中国科学院上海硅酸盐研究所（导师：施剑林）。研究工作主要围绕“纳米催化医学”，通过构建新型多功能的纳米药物在病灶处引发催化反应，调控局域活性氧浓度以达到疾病治疗的目的。现已第一/通讯作者身份发表SCI论文27篇，包括J. Am. Chem. Soc. 3篇、Nat. Commun. 2篇、Angew. Chem. Int. Ed. 5篇、Adv. Mater. 4篇、Chem 1篇、Chem. Rev. 1篇等。7篇论文入选ESI高被引，总引用次数超过4000。获得中国科学院院长特别奖、中国化学会菁青化学星火奖、京博优秀博士论文奖等荣誉和奖励。主持国家自然科学基金青年基金。入选上海市青年科技启明星。
联系方式
电话：021-52412706
工作经历
2024年11月-至今：中国科学院上海硅酸盐研究所，副研究员
2024年07月-2024年11月：中国科学院上海硅酸盐研究所，助理研究员
2022年07月-2024年07月：中国科学院上海硅酸盐研究所，博士后
教育经历
2017年09月-2022年06月：中国科学院上海硅酸盐研究所，博士
2013年09月-2017年07月：华东理工大学，学士
研究方向
I. 退行性疾病催化抗氧化治疗
II. 肿瘤纳米催化治疗
代表性论文
1. Di Jiang, Bowen Yang*, and Jianlin Shi. Antioxidative Therapy of Alcoholic Liver Injury by an Amorphous Two-Dimensional Cobalt Hydroxide Nanocatalyst. Angewandte Chemie International Edition 2024, 63, e202412031.
2. Bowen Yang, Chengkai Hu, Yuchong Zhang, Di Jiang, Peng Lin, Shouji Qiu, Jianlin Shi* and Lixin Wang*. Biomimetic-Structured Cobalt Nanocatalyst Suppresses Aortic Dissection Progression by Catalytic Antioxidation. Journal of the American Chemical Society 2024, 146, 17201-17210.
3. Jiacai Yang, Bowen Yang*, and Jianlin Shi*. A Nanomedicine-Enabled Ion-Exchange Strategy for Enhancing Curcumin-Based Rheumatoid Arthritis Therapy. Angewandte Chemie International Edition 2023, 62, e202310061.
4. Jiacai Yang, Heliang Yao, Yuedong Guo, Bowen Yang*, and Jianlin Shi*. Enhancing Tumor Catalytic Therapy by Co-Catalysis. Angewandte Chemie International Edition 2022, 61, e202200480.
5. Bowen Yang, Heliang Yao, Jiacai Yang, Chang Chen, and Jianlin Shi*. Construction of a Two-Dimensional Artificial Antioxidase for Nanocatalytic Rheumatoid Arthritis Treatment. Nature Communications 2022, 13, 1988.
6. Bowen Yang, Heliang Yao, Jiacai Yang, Chang Chen, Yuedong Guo, Hao Fu, and Jianlin Shi*. In Situ Synthesis of Natural Antioxidase Mimics for Catalytic Anti-Inflammatory Treatments: Rheumatoid Arthritis as an Example. Journal of the American Chemical Society2022, 144, 314-330.
7. Bowen Yang, Heliang Yao, Han Tian, Zhiguo Yu, Yuedong Guo, Yuemei Wang, Jiacai Yang, Chang Chen, and Jianlin Shi*. Intratumoral Synthesis of Nano-Metalchelate for Tumor Catalytic Therapy by Ligand Field-Enhanced Coordination. Nature Communications 2021, 12, 3393.
8. Bowen Yang and Jianlin Shi*. Ascorbate Tumor Chemotherapy by an Iron-Engineered Nanomedicine-Catalyzed Tumor-Specific Pro-Oxidation. Journal of the American Chemical Society 2020, 142, 21775-21785.
9. Bowen Yang, Yu Chen*, and Jianlin Shi*. Tumor-Specific Chemotherapy by Nanomedicine-Enabled Differential Stress Sensitization. Angewandte Chemie International Edition 2020, 59, 9693-9701.
10. Bowen Yang and Jianlin Shi*. Developing New Cancer Nanomedicines by Repurposing Old Drugs. Angewandte Chemie International Edition2020, 59, 21829-21838.
11. Bowen Yang, Li Ding, Heliang Yao, Yu Chen*, and Jianlin Shi*. A Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition. Advanced Materials 2020, 32, 1907152.
12. Bowen Yang, Yu Chen*, and Jianlin Shi*. Reactive Oxygen Species (ROS)-based Nanomedicine. Chemical Reviews 2019, 119, 4881-4985.
13. Bowen Yang, Yu Chen*, and Jianlin Shi*. Nanocatalytic Medicine. Advanced Materials 2019, 31, 1901778.
14. Bowen Yang, Junhui Yin, Yu Chen*, Shanshan Pan, Heliang Yao, Youshui Gao*, and Jianlin Shi* 2D-Black-Phosphorus-Reinforced 3D-Printed Scaffolds:A Stepwise Countermeasure for Osteosarcoma. Advanced Materials 2018, 30, 1705611.
专利
1. 一种具有催化抗氧化性能的二维金属有机框架纳米片及其制备方法和应用；ZL202210163113.8；施剑林，杨博文
2. 一种基于姜黄素的抗氧化纳米材料及其制备方法和应用；202310173856.8；杨博文，杨家财，施剑林
3. 一种金属有机框架纳米催化剂及其制备方法和应用；202410907440.9；杨博文，姜迪，施剑林
4. 一种氢氧化钴纳米片及其制备方法和应用；202410907443.2；杨博文，姜迪，施剑林
5. 一种二维氢氧化钛纳米片及其制备方法和应用；202411505360.7；杨博文，姚宇凡，施剑林
