SEMINAR
　　The State Key Lab of
　　High Performance Ceramics and Superfine Microstructure
　　Shanghai Institute of Ceramics, ChineseAcademy of Sciences
　　中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室

　　From Biomechanics to Mechanobiology and Mechanochemistry

—— Stem cells and surface topography

　　Speaker

　　龙勉　研究员

　　中国科学院力学研究所国家微重力实验室

　　时间：5月20日 （星期二）下午2:30

　　地点：4号楼14楼第一会议室

　　联系人：常江　研究员（2804）

　　Abstract:

　　Biomechanics mainly deals with stress-growth relation, that is, biological tissues and organs grow up in a stress field to possess their functions and stress distributions in the tissues and organs comply the need of functional optimization under physiological environments. Mechanobiology aims to understand the mechano-biological coupling, which focuses on defining mechanically-sensitive molecules and elucidating cellular responses induced by mechanical environment via transducing mechanical signals into chemical/biological signaling. Mechanochemistry tends to quantify how external force regulates the dissociation and binding kinetics of molecular interactions. In this presentation, multi-scale mechanobiological or mechanochemical approaches are integrated in unraveling the underlying mechanisms in inflammatory cascade and tumor metastasis. Specifically, the interplay of stem cell pluripotency and the niche microenvironment is discussed in the field of engineered tissue construction.

　　报告人简介：

　　龙勉教授于1984年毕业于上海交通大学，1990年在重庆大学获生物力学博士（中日联合培养），1996-1999曾年在美国Georgia Institute of Technology作高访学者，2002年获国家杰出青年基金，现任中科院力学所国家微重力实验室主任、生物力学与生物工程中心主任，中国力学学会理事会副理事长。龙勉教授从1990年起独立主持细胞-分子生物力学实验室，研究方向为蛋白质间相互作用与组装、细胞-亚细胞力学-生物学耦合以及抗体药物设计与评价、空间细胞-分子生物力学工程。在Nature、J. Biol. Chem.、Biophys. J.、Am. J. Physiol.-Cell Physiol.、Anal.Biochem.、Eur. Biophys.J.、Polymer、Ann. Biomed.Engi等杂志上发表SCI论文30余篇，获教育部首届“青年教师奖”、中国力学学会青年科技奖等荣誉。