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Biomaterials for cell and tissue engineering
发布时间:2015-12-29 点击浏览:

Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences


  Biomaterials for cell and tissue engineering

  Speaker:Prof. Song Li






  The biochemical and biophysical properties of biomaterials have profound effects on cell and tissue functions. We are interested in understanding how the biophysical properties such as the micro/nano structure and stiffness regulate cell behavior and how the bioactive materials can be used to promote tissue regeneration. Here I will discuss two examples: In vitro cell reprogramming and in vivo tissue regeneration. Stem cells are a valuable cell source for tissue engineering, disease modeling and drug screening. A recent discovery in stem cell biology is that differentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) and desired cell types. Although the effects of transcriptional factors and chemical compounds have been widely studied, the role of biophysical factors on cell reprogramming is not clear. I will present our findings on how biophysical factors can regulate the epigenetic state and thus the cell memory and reprogramming process, which has important implications in cell conversion into iPSCs and specific cell types. To illustrate the important role of biomaterials in tissue regeneration and remodeling in vivo, I will use blood vessel regeneration as an example to demonstrate an evolution from in vitro tissue engineering to in situ tissue engineering approach. In this approach, endogenous stem cells are recruited by the use of bioactive scaffolds to promote tissue regeneration.




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