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Development of multi functional nanostructures for biomedical imaging and treatment
报告人：Prof. Donglu Shi
The Institute for Advanced Materials and NanoBiomedicine
University of Cincinnati
日期：2008年9月12日（星期五）
上午10：00
地点：4号楼14楼第2会议室
联系人：常江
Tel: 52412804
Development of multi functional nanostructures for biomedical imaging and treatment
Donglu Shi
The Institute for Advanced Materials and Nano Biomedicine
There is currently an increasing need for early detection and treatment of cancer before anatomic anomalies are visible. A major challenge in cancer diagnosis is to be able to locally biomark the cancer cells in clinical pathology for maximum therapeutic benefit. In cancer therapy, targeting and localized treatment are also the key challenges. One promising strategy for overcoming these challenges is to make use of highly fluorescent nanoparticles for qualitative or quantitative in vivo detection of tumor cells. However, an optimum nanostructure is yet to be developed with multiple functionalities including intensive fluorescence, effective drug storage capability, and therapeutic means. In this presentation, we report here a scheme of new nanostructure design that ideally satisfies these important requirements. By novel surface engineering, multiple functionalities are developed in a nano assembly for both in vivo imaging and treatment. Such a nano assembly possesses several uniquely combined functionalities including strong fluorescence, anti cancer drug storage, and hyperthermia. In this way, it is possible that early cancer diagnosis and local treatment can be achieved simultaneously. HRTEM, fluorescence spectroscopy, in vivo imaging experimental results will be presented on the surface nanostructures, optical properties, and cancer diagnosis.
Biographical Sketch
Donglu Shi received his M. S. (in Physics) in 1983 and Ph. D. (in Superconductivity) in 1986 from the University of Massachusetts at Amherst. After graduation, he took a Staff Scientist position at the Materials Science Division of Argonne National Laboratory in 1987 (first year as a posdoc). At Argonne, he was a principle investigator for a major Department of Energy program on High-Tc superconductors. In the fall of 1995, Donglu Shi joined the faculty as an Associate Professor in the Department of Materials Science and Engineering at University of Cincinnati. He was promoted to the full professor position in 2001 at University of Cincinnati. Donglu Shi has so far published 200 refereed journal publications including Physical Review Letters, Nature, and Advanced Materials. He has edited six books in superconductivity, functional thin films, nanomaterials, biomaterials, and tissue engineering (Pergamon Press, Springer-Verlag, and Tsinghua University Press). He has also edited six special issues of Materials Science & Engineering, Nano Research, J. of Nanomaterials, Applied Superconductivity and MRS Bulletin. He holds seven US patents in electronic materials. He is currently serving on the editorial board of J. of Nanomaterials, Tsinghua Science and Technology, and 21 Century Science and Technology Frontier Book Series (Springer-Verlag and Tsinghua University Press). He has won the SIGMA XI Research Recognition Award, Honor Roll Professor Award, and Neil Wandmecher Teaching Award. Donglu Shi’s main interests include nanomaterials, superconducting materials, and biomaterials. The most recent works on nanomaterials pioneer a novel approach in the deposition of an ultrathin polymer film (2 nm thick) on nanoparticles and nanotubes via plasma polymerization. The surface-coated carbon nanotubes have shown unique properties in composite polymers and ceramics. His current research also deals with luminescent nanotubes for cancer diagnosis and treatment. The current research on in vivo imaging by luminescent nanotubes has paved a new path to early detection of cancer.
