Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Manufacturing Goes Viral:
Biomimetic Self-templating Assembly and Applications
Speaker： Professor Seung-Wuk Lee
(University of California, Berkeley)
In nature, helical macromolecules such as collagen, chitin and cellulose are critical to the morphogenesis and functionality of various hierarchically structured materials. During morphogenesis, these chiral macromolecules are secreted and undergo self-templating assembly, a process whereby multiple kinetic factors influence the assembly of the incoming building blocks to produce non-equilibrium structures. A single macromolecule can form diverse functional structures when self-templated under different conditions. Collagen type I, for instance, forms transparent corneal tissues from orthogonally aligned nematic fibers, distinctively colored skin tissues from cholesteric phase fiber bundles, and mineralized tissues from hierarchically organized fibers. Nature’s self-templated materials surpass the functional and structural complexity achievable by current top-down and bottom-up fabrication methods. However, self-templating has not been thoroughly explored for engineering synthetic materials.
In my seminar, I will demonstrate a facile biomimetic process to create functional nanomaterials utilizing chiral colloidal particles (M13 phage). A single-step process produces long-range-ordered, supramolecular films showing multiple levels of hierarchical organization and helical twist. Using the self-templating materials assembly processes, we have created various biomimetic supramolecular structures. The resulting materials show distinctive optical and photonic properties, functioning as chiral reflector/filters and structural color matrices. Through the directed evolution of the M13 phages, I will also show how resulting materials can be utilized as functional nanomaterials for biomedical, biosensor and bioenergy applications.
Professor Lee earned his B.S and M.S. from Korea University (Seoul) and his Ph.D. from the University of Texas at Austin (2003). After a postdoctoral fellowship at Lawrence Berkeley National Lab, he joined a faculty position at UC Berkeley in 2006, was promoted to Associate Professor (2011) with tenure, a full professor (2015). He is also Associate Director of the Center of Integrated Nanomechanical Systems at UCB and Scientist, LBNL Physical Bioscience Division. The Lee group uses chemical and biological approaches to create precisely defined nanomaterials, to investigate complex phenomena at their interfaces, and to develop novel, biomimetic, functional materials. Among other awards, Professor Lee is R&D 100 Award (2013) and an NSF CAREER awardee. Dr. Lee’s on going research was chosen as one of 12 highlight researches chosen by the President Obama’s National Science Foundation Report for the US Congress entitled “Manufacturing Goes Viral” (2014) and chosen as one of top five Future Nanomanufacturings by Scientific American (2013).